报告时间：2023年12月11日（周一）10:00

报告地点: 物质科研楼A309会议室

报告题目：Diamond-based quantum sensing for biophysics and bioanalytics

报告人: 谢谋哲 Assistant Professor (Arizona State University)

报告摘要：

   Quantum sensing technologies enable some of the most precise measurements that human beings have ever achieved. In recent years, optically addressable nitrogen-vacancy (NV) color center hosted by diamond crystal has been used as a novel quantum sensor, which has exquisitely sensitive response to local magnetic field fluctuations. It is therefore capable to perform micro-/nano-scale NMR experiments, manifesting enormous potential to study biological systems on extremely small sample volume – even down to single-molecule regime.

In this presentationI will discuss some of the comprehensive efforts to develop NV-based quantum sensing platforms for a wide range of applications in chemistry and biology.I will start with a general introduction to quantum sensing followed by conventional NMR spectroscopy as a powerful tool to study biomolecules, as well as their connections to the NV-based nanoscale NMR. I will then introduce a biocompatible surface functionalization architecture for interfacing a diamond quantum sensor with individual intact biomolecules under physiological conditions. A sensing modality based on diamond membrane integrated with flow channel will also be discussed, which is a promising platform for a variety of experiments a molecular, cellular, and even living-organism levels. Finally, I will conclude by providing an outlook on how NV-based quantum sensing platforms, combined with other advanced spectroscopy and microscopy methods, can be utilized to address important biophysical and bioanalytical questions with unprecedented sensitivity and spatial resolution, which will enhance our understanding of molecular interactions and cellular processes and ultimately improve human health.

报告人简介：

Mouzhe Xie is an Assistant Professor in the School of Molecular Sciences at Arizona State University (Tempe). He received a B.S. degree in Chemical Biology from Xiamen University, China, in 2013. From 2013 to 2018, Mouzhe conducted Ph.D. research in the Department of Chemistry and Biochemistry at The Ohio State University, under the advisory of Prof. Rafael Brüschweiler. Availing himself of the Campus Chemical Instrument Center - NMR facility (now the National Gateway Ultrahigh Field NMR Center), he developed and applied NMR spectroscopy and spin control techniques to investigate topics ranging from biophysics, protein dynamics, structural biology, and metabolomics. From 2019 to 2023, Mouzhe did his postdoctoral research in the laboratory of Prof. Peter Maurer, firstly at the École polytechnique fédérale de Lausanne (EPFL), Switzerland, and later moved to the Pritzker School of Molecular Engineering at the University of Chicago. During this time, he expanded his expertise in NMR and biophysics to develop diamond-based quantum sensing technology for chemical and biological applications, as well as worked extensively on diamond material engineering. The integration of these technologies leads to novel sensing platforms for molecular analytics, drug discovery, and disease diagnosis, and ultimately reshape the landscape of healthcare for the better.