陈三友 研究员
发布人:中科院微观磁共振重点实验室  发布时间:2020-05-20   动态浏览次数:233

姓名:

陈三友 特任研究员

工作单位:

中国科学技术大学生物医学工程学院

中国科学院微观磁共振重点实验室

E-mail:

sanyou@ustc.edu.cn


陈三友,男,中国科学技术大学特任研究员,博士生导师。主要从事微观磁共振技术及其生物医学应用交叉研究,同时开展细胞内膜转运的调控机制及相关疾病研究。利用金刚石量子传感器,开发出微米分辨率的肿瘤组织免疫磁成像技术、纳米分辨率的细胞磁成像技术、单分子灵敏度的生物分子相互作用磁学检测技术;发现了线虫肠细胞中一种新的囊泡循环转运模式,并阐明了相关调节机制。主要研究成果以第一或共同第一作者发表在国际学术期刊Proc Natl Acad Sci U S AScience AdvancesNano Letters上。共申请发明专利5项,其中授权1项。主持包括国家重点研发计划课题在内的科研项目共8项。曾获量子信息与量子科技前沿协同创新中心优秀博士后奖


  • 学历:

200409月-200806月,华中科技大学,生命科学与技术学院,学士

200809月-201412月,华中科技大学,生命科学与技术学院,博士


  • 主要工作经历:

201501月-201712,中国科学技术大学,物理学院,博士后

201801月-202209月,中国科学技术大学,物理学院,特任副研究员

202209月至今,中国科学技术大学,生物医学工程学院,特任研究员


  • 目前主持的主要科研项目:

1.科技部国家重点研发计划,室温超高灵敏度量子磁敏感元件及传感器,课题负责人,2021.12-2024.11

2.国家自然科学基金面上项目,基于单颗粒磁成像的蛋白质相互作用检测方法研究,主持,2021.01-2024.12


  • 代表性研究论文:

1. Sanyou Chen#, Ziting Sun#, Wanhe Li#, Pei Yu#, Qian Shi, Fei Kong, Qi Zhang, Pengfei Wang, Ya Wang, Fazhan Shi*, and Jiangfeng Du*. Digital Magnetic Detection of Biomolecular Interactions with Single Nanoparticles. Nano Letters 23, 2636-2643, (2023).

2. Sanyou Chen#, Wanhe Li#, Xiaohu Zheng#, Pei Yu, Pengfei Wang, Ziting Sun, Yao Xu, Defeng Jiao, Xiangyu Ye, Mingcheng Cai, Mengze Shen, Mengqi Wang, Qi Zhang, Fei Kong, Ya Wang, Jie He, Haiming Wei, Fazhan Shi*, and Jiangfeng Du*. Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond. Proc Natl Acad Sci U S A 119(5), e2118876119 (2022).

3. Wei Yi-Cheng, Yu Pei, Chen Ming, Sun Zi-Ting, Zeng Yan, Lou Ji-Zhong, Chen San-You*, Shi Fa-Zhan*, Du Jiang-Feng. Preparation of DNA Origami for Ordered Immobilization of Single Molecules on Diamond Surface. Progress in Biochemistry and Biophysics 47(1), 53-60 (2020).

4. Pengfei Wang#, Sanyou Chen#, Maosen Guo#, Shijie Peng#, Mengqi Wang, Ming Chen, Wenchao Ma, Rui Zhang, Jihu Su, Xing Rong, Fazhan Shi, Tao Xu*, Jiangfeng Du*. Nanoscale magnetic imaging of ferritins in a single cell. Science Advances 5(4), eaau8038 (2019).

5. Sanyou Chen#, Lei Li#, Jiangli Li#, Bei Liu, Xinyu Zhu, Li Zheng, Rongying Zhang*, Tao Xu*. SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans. Proc Natl Acad Sci U S A111(43), 15432-15437 (2014).

6. Zhuoyang Qin#, Zhecheng Wang#, Fei Kong*, Jia Su, Zhehua Huang, Pengju Zhao, Sanyou Chen, Qi Zhang, Fazhan Shi* & Jiangfeng Du*. In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors. Nature Communications 14, 6278 (2023).

7. Qi Zhang#, Jun Yin#, Yihao Yan, Sanyou Chen, Bingyan Wei, Sheng Zhao, Min Li, Ming Lei, Yiheng Lin*, Fazhan Shi*, and Jiangfeng Du*. Biocompatible Nanotomography of Tightly Focused Light. Nano Letters 22, 1851-1857 (2022).

8. Bin Hu#, Wenping Zeng#,*, Xia Li#, Umar Al-Sheikh, Sanyou Chen, and Jiuping Ding*. A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity. Channels13(1), 483-497 (2019).

9. Fazhan Shi#, Fei Kong#, Pengju Zhao#, Xiaojun Zhang, Ming Chen, Sanyou Chen, Qi Zhang, Mengqi Wang, Xiangyu Ye, Zhecheng Wang, Zhuoyang Qin, Xing Rong, Jihu Su, Pengfei Wang, Peter Z. Qin*, and Jiangfeng Du*. Single-DNA electron spin resonance spectroscopy in aqueous solutions. Nature Methods 15(9), 697-699 (2018).

10. Tianyu Xie#, Fazhan Shi#, Sanyou Chen, Maosen Guo, Yisheng Chen, Yixing Zhang, Yu Yang, Xingyu Gao, Xi Kong, Pengfei Wang, Kenichiro Tateishi, Tomohiro Uesaka, Ya Wang, Bo Zhang*, and Jiangfeng Du*. Mesoscopic Magnetic Resonance Spectroscopy with a Remote Spin Sensor. Physical Review Applied 9(6), 064003 (2018).